To understand the molecular mechanisms of the enhancement of

Figure options The combination of CXCL7 and SDF1 increase TRAP-positive 158171-14-3 and promote the formation of giant osteoclasts To search for the dominant chemokines involved in IGF2 stimulation, we examined the effects of SDF1 and CXCL7 on osteoclast differentiation using mouse bone marrow cells. The addition of exogenous CXCL7 increased the number of osteoclastic TRAP-positiveContinue reading »

The TSAd SH domain is a type I SH domain

Fig. 1. TSAd interacts with Smad2 and Smad3. (A) GST-TSAd or GST was incubated with extracts from COS-7 158171-14-3 untransfected (-) or transfected with FLAG-tagged Smad2 (S2), Smad3 (S3) or Smad4 (S4). Proteins associated with GST-TSAd and GST after pull-down with glutathione–Sepharose 4B were subjected to Western blot (WB) using anti-FLAG and anti-GST antibodies. WBContinue reading »